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The water-soluble antioxidant, 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic (Trolox), (4-14C)-labelled, was used to trace its location in the aqueous and lipid phases of liposomes. Trolox was found to partition 20 to 25% into the lipid phase of multilamellar (MLV) and 38-46% into the lipid phase of unilamellar (ULV) egg lecithin liposomes. Trolox and(More)
BACKGROUND There is a clinical requirement for longer-acting local anesthetics, particularly for the management of post-operative and chronic pain. In this regard, liposomes have been suggested to represent a potentially useful vehicle for sustained drug release after local administration. In the current study, the authors used a transmembrane pH gradient(More)
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