J. J. Misiewicz

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There is considerable confusion over the management of Helicobacter pylori infection, particularly among primary care physicians, and numerous European countries lack national guidelines in this rapidly growing area of medicine. The European Helicobacter Pylori Study Group therefore organised a meeting in Maastricht of H pylori experts, primary care(More)
Belleville, R. E., and Fraser, H. F. (1957). J. Pharmacol. exp. Ther., 120, 469. Berger, R. J., and Oswald, I. (1962). 7. ment. Sci., 108, 457. Collier, H. 0. J. (1965). Nature (Lond.), 205, 181. Dement, W. (1960). Science, 131, 1705. and Kleitman, N. (1957). Y. exp. Psychol., 53, 339. Evans, J. I., and Oswald, I. (1965). Electroenceph. clin. Neurophysiol.,(More)
There is no ideal method for detecting Helicobacter pylori. The 'standard' 13Carbon urea breath test (13C-UBT), which involves collecting eight to 15 breath samples and subsequent costly analysis, was modified by pooling 21 samples of expired breath taken at five minute intervals for 40 minutes into a collecting bag, from which a single 20 ml aliquot was(More)
Sixteen subjects (mean (s.d.) age 50.7 (12.8) years, three men) were studied on two separate occasions by two experienced investigators in random order. A standard protocol of anatomical, manometric and electrophysiological assessments of anorectal motor and sensory function was followed. No significant differences were found between the results obtained by(More)
The possibility that malabsorbed fat passing through the human ileum exerts an inhibitory feedback control on jejunal motility has been investigated in 24 normal subjects by perfusing the ileum with a fat containing solution designed to produce ileal luminal fat concentrations similar to those in steatorrhoea (30-40 mg/ml). Mean transit times through a 30(More)
Omeprazole is a powerful inhibitor of gastric acid and may suppress Helicobacter pylori by effecting the pKa of H pylori urease, by altering the pattern of infection, or by promoting overgrowth of other bacteria. At routine endoscopy H pylori was detected by histology and culture before and after four weeks' treatment with omeprazole, 40 mg each morning. A(More)
Previous studies have shown that ileal infusion of partially digested triglyceride inhibits jejunal motility. The partial digest used in those studies contained a mixture of glycerol, free fatty acid, mono-, di-, and triglycerides. In Part I of the present study we have separately infused emulsions containing either glycerol 3.1 g (n = 6), oleic acid 9.6 g(More)
Prostaglandins may be involved in the control of human gastrointestinal motility or may constitute the humoral agent responsible for the diarrhea associated with medullary carcinoma of the thyroid. This study examines the effects of oral PGE1 on intestinal transit and motility in 4 healthy adult male volunteers with no gastrointestinal symptoms and who(More)