J J Lospalluto

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The occurrence of antibodies of different molecular size in man and experimental animals has long been known (1). In recent years increasing attention has been focused on the group with high molecular weight (19S), which includes not only a number of well defined antibodies but, in addition, certain substances with similar electrophoretic and(More)
Evidence has been found to document the presence of circulating immune complexes in all patients with Felty's syndrome. The sera of all 12 patients studied showed intermediate complexes by analytical ultracentrifugation. The sera of 9 of 12 patients (75%) showed precipitin lines upon immunodiffusion against IgM rheumatoid factor. Both findings were(More)
Initial studies, by using polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate (SDS), led to the attractive hypothesis that the cholera exo-enterotoxin (choleragen) consisted of two noncovalently linked peptides of 56,000 and 28,000 molecular weight. The spontaneous toxoid (choleragenoid) appeared to be identical with the 56,000(More)