The computer program HYLAS generates from a standard DNA letter sequence a three-dimensional space curve (H curve) which embodies the entire information content of the original nucleotide sequence. The program can display H curves either as two-dimensional (front and side view) projections or as stereo-pair images. The curves can be marked at specific… (More)
We analyzed both trigeminal ganglia of eight post-mortem human subjects for their content of neurons and non-neuronal cells using dissociated cell suspension techniques. Neuronal counts in each of the 16 ganglia ranged from 20,000 to 35,400, with an average of 27,400 +/- 4800, and the estimated ratio of non-neuronal to neuronal cells was 100 to 1. Our… (More)
Polymerase chain reaction and immunohistochemical analyses of formalin-fixed temporal arteries from 10 pathologically verified cases of giant cell arteritis did not reveal varicella zoster virus antigen or DNA.
PURPOSE Cellular mechanisms activated during seizures may exacerbate epilepsy. gamma-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in brain, and we hypothesized that brief epileptic seizures may reduce GABA function. METHODS We used audiogenic seizures (AGSs) in genetically epilepsy-prone rats (GEPRs) to investigate effects of seizures… (More)