J. J. Florentin

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The elimination of hepatitis C virus (HCV) in > 50% of chronically infected patients by treatment with IFN-α suggests that plasmacytoid dendritic cells (pDCs), major producers of IFN-α, play an important role in the control of HCV infection. However, despite large amounts of Toll-like receptor 7-mediated IFN-α, produced by pDCs exposed to HCV-infected(More)
Plasmacytoid dendritic cells (pDCs) respond to viral infection by production of alpha interferon (IFN-α), proinflammatory cytokines, and cell differentiation. The elimination of hepatitis C virus (HCV) in more than 50% of chronically infected patients by treatment with IFN-α suggests that pDCs can play an important role in the control of HCV infection. pDCs(More)
Crosslinking of regulatory immunoreceptors (RR), such as BDCA-2 (CD303) or ILT7 (CD85g), of plasmacytoid dendritic cells (pDCs) efficiently suppresses production of type-I interferon (IFN)-α/β and other cytokines in response to Toll-like receptor (TLR) 7/9 ligands. This cytokine-inhibitory pathway is mediated by spleen tyrosine kinase (Syk) associated with(More)
Items in business systems have to be identified by reference codes, which can later be used as data codes and file keys in an associated data processing system. In business systems associated with large collections of integrated files (databases) it is vital to assign codes in a methodical way so as to control future extension and changes while maintaining(More)
Introduction Plasmacytoid dendritic cells (pDCs) respond to viral infection by production of interferon a (IFN-a), proinflammatory cytokines and cell differentiation. The elimination of hepatitis C virus (HCV) in more than 50% of chronically infected patients by treatment with IFN-a suggests that pDCs can play an important role in the control of HCV(More)
We have designed several interactive computer systems for financial analysts. In early designs we treated the analysts-computer interactive dialogue at a computer terminal as being isolated from group considerations. In a later system we were forced to make extensive technical changes to take account of data storage sharing. This sharing of data storage had(More)
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