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Mice that overexpress the human mutant amyloid precursor protein (hAPP) show learning deficits, but the apparent lack of a relationship between these deficits and the progressive beta-amyloid plaque formation that the hAPP mice display is puzzling. In the water maze, hAPP mice are impaired before and after amyloid plaque deposition. Here we show, using a(More)
To assess the interaction between spatial and procedural memory systems, the authors developed a learning protocol in the water maze using a rising "Atlantis" platform that requires rats to learn to swim to a specific location and, once there, to learn a "dwelling" response to raise the platform. In this protocol, the effects of temporal inactivation of the(More)
Some parameters of the electromyographic power spectrum of the paraspinal muscles were recorded and analyzed with regard to their ability to discriminate between normal controls and patients with back pain classified as "avoiders" or "confronters" by their responses to the Pain Behavior Checklist. In terms of the activity of the multifidus muscle, the(More)
A long-term, comparison-group outcome trial with a partial crossover design was carried out on the effects of electromyographic biofeedback (EMGBF) plus physiotherapy (PT) versus PT alone in the treatment of the hemiplegic upper limb in stroke patients who were at least six months beyond the onset of their disability. Both the experimental and the control(More)
One hundred subjects (50 men, 50 women), of whom 80 had suffered a unilateral cerebrovascular accident (40 left, 40 right), were tested on the WAIS. In the case of left hemisphere damage the male patients showed lower Verbal than Performance Scale IQ scores; for the right brain damaged men Performance Scale scores were Lower than their scores on the Verbal(More)
The aim of this study was to assess the effect on EMG amplitude measures of variations in the thickness of underlying tissue between surface electrodes and the active muscle. 20 normal subjects with different amounts of subcutaneous tissue performed comparable constant force contractions for a 45-second period, during which paraspinal EMG recordings were(More)
Fifty-nine patients suffering from a major depressive episode, for whom electroconvulsive therapy (ECT) was clinically indicated, were randomly assigned to one of three electrode placement groups for treatment with brief pulse, threshold-level ECT: bitemporal (BT), right unilateral (RU) or bifrontal (BF). Comparison of these groups in terms of number of(More)
Forty patients suffering from a major depressive disorder, for whom electroconvulsive therapy (ECT) was clinically indicated, were assigned to one of three electrode placement groups: bitemporal (BT), right unilateral (RU) or bifrontal (BF). Comparisons of these groups in terms of cognitive status showed that the BF placement, which avoided both temporal(More)
The unrotated principal components analysis of the WISC-R normative data yields a bipolar factor 2 which corresponds to a verbal-non-verbal continuum of test material. A review of published WISC-R and WISC data from learning disabled (LD) children reveals that the amount of deficit shown by these children on any particular subtest is closely proportional to(More)