8G. Passaleva
8M.-O. Bettler
8M. Merk
8C. Frei
8T. M. Karbach
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Mitochondrial ribosomes and translation factors co-purify with mitochondrial nucleoids of human cells, based on affinity protein purification of tagged mitochondrial DNA binding proteins. Among the most frequently identified proteins were ATAD3 and prohibitin, which have been identified previously as nucleoid components, using a variety of methods. Both(More)
Mitochondrial DNA maintenance and segregation are dependent on the actin cytoskeleton in budding yeast. We found two cytoskeletal proteins among six proteins tightly associated with rat liver mitochondrial DNA: non-muscle myosin heavy chain IIA and β-actin. In human cells, transient gene silencing of MYH9 (encoding non-muscle myosin heavy chain IIA), or the(More)
The accessory subunit of mitochondrial DNA polymerase gamma, POLGbeta, functions as a processivity factor in vitro. Here we show POLGbeta has additional roles in mitochondrial DNA metabolism. Mitochondrial DNA is arranged in nucleoprotein complexes, or nucleoids, which often contain multiple copies of the mitochondrial genome. Gene-silencing of POLGbeta(More)
The bacterial homologue of C4orf14, YqeH, has been linked to assembly of the small ribosomal subunit. Here, recombinant C4orf14 isolated from human cells, co-purified with the small, 28S subunit of the mitochondrial ribosome and the endogenous protein co-fractionated with the 28S subunit in sucrose gradients. Gene silencing of C4orf14 specifically affected(More)
The non-deterministic nature of photon sources is a key limitation for single-photon quantum processors. Spatial multiplexing overcomes this by enhancing the heralded single-photon yield without enhancing the output noise. Here the intrinsic statistical limit of an individual source is surpassed by spatially multiplexing two monolithic silicon-based(More)
  • R. Aaij, C. Abellan Beteta, B. Adeva, M. Adinolfi, C. Adrover, A. Affolder +494 others
  • 2012
Measurement of ψ(2S) meson production in pp collisions at √ s = 7 TeV Abstract The differential cross-section for the inclusive production of ψ(2S) mesons in pp collisions at √ s = 7 TeV has been measured with the LHCb detector. The data sample corresponds to an integrated luminosity of 36 pb −1. The ψ(2S) mesons are reconstructed in the decay channels(More)
The amino acid metabolism in patients with hepatitis B virus (HBV) infection is significantly changed. In this study, we analyzed the relationship between the amino acid profiles and varying clinical stages of HBV infection, and investigated their significance. The plasma amino acid concentrations in 115 patients with HBV infection and 32 healthy donors(More)
Effective treatment of infectious diseases depends on the ability to rapidly identify the infecting bacteria and the use of sensitive antibiotics. The currently used identification assays usually take more than 72 h to perform and have a low sensitivity. Herein, we present a microbead-based microfluidic platform that is highly sensitive and rapid for(More)
  • R. Aaij, C. Abellan Beteta, B. Adeva, M. Adinolfi, C. Adrover, A. Affolder +494 others
  • 2013
An angular analysis of the decay J /ψ → μ + μ − is performed to measure the polarization of prompt J /ψ mesons produced in pp collisions at √ s = 7 TeV. The dataset corresponds to an integrated luminosity of 0.37 fb −1 collected with the LHCb detector. The measurement is presented as a function of transverse momentum, p T , and rapid-ity, y, of the J /ψ(More)