J. Havrdová

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In rat bile, Mn2+ cations bound to substances of low molecular weight. Substances of still lower molecular weight were formed, in the presence of Mn2+. It is suggested that the substances in question were bile pigments loosened from their carriers in the bile under the influence of Mn2+. The changes in the bile composition occurred in bothin vivo andin(More)
The effects of dosage and of cadmium pretreatment on the binding of cadmium in rat bile were studied. With increasing dose a higher cumulative biliary excretion of Cd was observed and a higher percentage of the Cd was excreted in a low-molecular-weight form. On the other hand, after cadmium pretreatment, a decrease in the cumulative biliary excretion of(More)
An epidemiological study was performed to assess whether environmental pollution by cadmium as found in cadmium polluted areas of CSFR (Pribram and Frýdek-Mistek) is associated with changes in biological indicators of renal dysfunction in non-occupationally exposed population groups. Polluted areas were chosen on the basis of existing sources of Cd(More)
The distribution of 110mAg in the elution fractions obtained from gel filtration (Sephadex G-75) of the supernatants of rat liver homogenates was studied. 110mAgNO3 was administered i.v. at the doses 0.183 and 0.912 mg Ag+ . kg-1 . b . wt.and rats were killed 30 min after the administration. Differential centrifugation of the homogenates was performed to(More)
The effect of single i.v. injection of 110mAgNO3 (0.183 mg Ag+ X kg-1 b.wt.) in rats on the ceruloplasmin oxidase activity (Cp) and copper serum concentration was studied. It was found that Cp activity in the serum decreased to 70% of the control value and simultaneously serum copper concentration decrease to 30% of the control level. In both cases the(More)
The binding of copper and zinc with substances contained in the rat bile was studied in the course of 24 h after intravenous administration of CuCl2 or ZnCl2. The bile was fractionated using column chromatography on Sephadex G-100 and in case of zinc also by the method of disc electrophoresis on polyacrylamide gel. It was ascertained that both zinc and(More)
After cannulation the bile duct of unexposed rats, changes in bilirubin concentration in the samples of bile collected were observed. During the first hour after the cannulation the bilirubin concentration decreased remaining constant until about the 3.-4. hour and then continuously increased upto the 24. hour when the experiment ended. The final(More)
In a 61-year-old woman, who had been exposed for 20 years to cadmium in the production of Ni-Cd batteries, nephrectomy of the contracted kidney was performed. The removed kidney was examined histologically and the cadmium concentration was determined in the cortex (44.97 micrograms g-1) and in the medulla (7.71 micrograms g-1). The homogenates of the renal(More)
While an inorganic mercury compound was excreted in rats via bile with substances of high molecular weight only (fraction 1), MeHg and PhHg compounds were excreted with substances of both high and low (fraction 2) molecular weights. The rate of enterohepatic circulation of the compounds increased and their total excretion from rats decreased with the(More)
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