J. Hansen

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BACKGROUND Lipopolysaccharide (LPS) is a major trigger of sepsis-induced disseminated intravascular coagulation (DIC) via the tissue factor (TF)/factor VIIa-dependent pathway of coagulation. Experimental endotoxemia has been used repeatedly to explore this complex pathophysiology, but little is known about the effects of clinically used anticoagulants in(More)
During sepsis, lipopolysaccharide (LPS) triggers the development of disseminated intravascular coagulation (DIC) via the tissue factor-dependent pathway of coagulation resulting in massive throm-bin generation and fibrin polymerization. Recently, animal studies demonstrated that hirudin reduced fibrin deposition in liver and kidney and decreased mortality(More)
The impact on the physics capabilities of the ATLAS detector of possible LHC upgrades is discussed. As a benchmark, an increase in the luminosity by a factor of ten is considered. For comparison, a doubling of the LHC energy is also explored. Both upgrades significantly enhance the physics capabilities of ATLAS. As measured in terms of the mass reach for(More)
In this work, we present the development of a transparent poly(methyl methacrylate) (PMMA) based microfluidic culture system for handling long-term brain slice cultures independent of an incubator. The different stages of system development have been validated by culturing GFP producing brain slices from 8-day old (P8) mouse pups. Fluorescence microscopic(More)
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