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The diabetes insipidus dog is more susceptible to hemorrhage than the normal dog as determined by a standardized hemorrhage procedure. When aqueous pitressin is administered in subpressor dosages, this susceptibility to hemorrhage is reversed to or toward normal. Aqueous pitressin does not increase the intact dog's resistance to hemorrhage. The foregoing(More)
The duration of action of single oral doses of 80 and 160 mg of propranolol during acute and sustained therapy was studied in nine patients with stable, exercise-induced angina pectoris. Plasma propranolol levels peaked 2 hours after both doses during acute and sustained therapy, but there were wide variations between individuals in plasma concentration(More)