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The incubation of slices of cerebral cortex under hyperbaric oxygen pressures from 1 to 10 atmospheres in the presence of radioactive glucose, pyruvate, succinate, fumarate, L-glutamate, and gamma-aminobutyric acid causes a marked diminution of tissue oxidative reactions. There is a simultaneous decrease in phosphocreatine and adenosine triphosphate, and a(More)
The uptake of radioactive l-phenylalanine and l-tyrosine into the tissue water of rat brain cerebral cortex slices was shown to have saturation kinetics. The apparent K(m) for the uptake of l-phenylalanine was 0.86mm and for l-tyrosine was 1.64mm; for phenylalanine the apparent V(max.) value was 0.64mumol/min per ml of tissue water, and for l-tyrosine it(More)
Piridoxilate, at the concentration of 120 mg/kg i.p. in rats, enhanced resistance of these animals to hypoxia (N2 : O2 3,2 %). The electrocorticogram (ECOG) is used to indicate the effectiveness of the drug in lowering the time of electrographic silence, on control (n=19) and pretreated rats (n=12). The ECOG was recorded also during the recovery period(More)