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The TLR-mediated response of plasmacytoid dendritic cells is positively regulated by estradiol in vivo through cell-intrinsic estrogen receptor α signaling.

• Cyril Seillet, Sophie Laffont, +6 authors J Guery
• Blood
• 2012

Plasmacytoid dendritic cells (pDCs) produce large amounts of type I interferons (IFN-α/β) in response to viral or endogenous nucleic acids through activation of their endosomal Toll-like receptors… (More)

Estrogen receptor alpha signaling in inflammatory leukocytes is dispensable for 17beta-estradiol-mediated inhibition of experimental autoimmune encephalomyelitis.

• Lucile Garidou, Sophie Laffont, +4 authors J Guery
• Journal of immunology
• 2004

Estrogen treatment has been shown to exert a protective effect on experimental autoimmune encephalomyelitis (EAE), and is under clinical trial for multiple sclerosis. Although it is commonly assumed… (More)

Endothelial estrogen receptor-alpha plays a crucial role in the atheroprotective action of 17beta-estradiol in low-density lipoprotein receptor-deficient mice.

• Audrey Billon-Galés, Coralie Fontaine, +8 authors J A Arnal
• Circulation
• 2009

BACKGROUND The prevention of early atheroma by estrogens has been clearly demonstrated in all animal models and appears to be mediated through a direct action on the arterial wall rather than through… (More)

Estradiol promotes functional responses in inflammatory and steady-state dendritic cells through differential requirement for activation function-1 of estrogen receptor α.

• Cyril Seillet, Nelly Rouquié, +6 authors Sophie Laffont
• Journal of immunology
• 2013

17β-Estradiol (E2) has been shown to regulate GM-CSF- or Flt3 ligand-driven dendritic cell (DC) development through estrogen receptor (ER) α signaling in myeloid progenitors. ERα regulates… (More)

Chronic estradiol administration in vivo promotes the proinflammatory response of macrophages to TLR4 activation: involvement of the phosphatidylinositol 3-kinase pathway.

• Bertrand Calippe, Victorine Douin-Echinard, +7 authors Pierre Gourdy
• Journal of immunology
• 2008

Short-term exposure to 17beta-estradiol (E2) in vitro has been reported to decrease the production of proinflammatory cytokines by LPS-activated macrophages through estrogen receptor alpha… (More)

Knocking down Cav1 calcium channels implicated in Th2 cell activation prevents experimental asthma.

• Marilena Djata Cabral, Pierre-Emmanuel Paulet, +12 authors Lucette Pelletier
• American journal of respiratory and critical care…
• 2010

RATIONALE Th2 cells orchestrate allergic asthma and the cytokines they produce (IL-4, IL-5, and IL-13) are deleterious in allergy. Therefore, it is important to identify key signaling molecules… (More)

Estrogen enhances susceptibility to experimental autoimmune myasthenia gravis by promoting type 1-polarized immune responses.

• Laurent Delpy, Victorine Douin-Echinard, Lucile Garidou, Corinne Bruand, Abdelhadi Saoudi, J Guery
• Journal of immunology
• 2005

Myasthenia gravis (MG) is an organ-specific autoimmune disease caused in most cases by autoantibodies against the nicotinic acetylcholine receptor (AChR). It is now well documented that many… (More)

17Beta-estradiol promotes TLR4-triggered proinflammatory mediator production through direct estrogen receptor alpha signaling in macrophages in vivo.

• Bertrand Calippe, Victorine Douin-Echinard, +8 authors Pierre Gourdy
• Journal of immunology
• 2010

17Beta-estradiol (E2) has been shown to promote the expression of inflammatory mediators by LPS-activated tissue resident macrophages through estrogen receptor alpha (ERalpha) signaling. However, it… (More)

Natural killer cells recruited into lymph nodes inhibit alloreactive T-cell activation through perforin-mediated killing of donor allogeneic dendritic cells.

• Sophie Laffont, Cyril Seillet, John R. Ortaldo, Jerome D Coudert, J Guery
• Blood
• 2008

Natural killer (NK)-cell alloreactivity is exploited in bone marrow transplantation to improve clinical outcome. Likewise, in solid organ transplantation, it has been recently shown that recipient NK… (More)

Estrogen receptor alpha, but not beta, is required for optimal dendritic cell differentiation and [corrected] CD40-induced cytokine production.

• Victorine Douin-Echinard, Sophie Laffont, +6 authors J Guery
• Journal of immunology
• 2008

Dendritic cells (DC) are critical actors in the initiation of primary immune responses and regulation of self-tolerance. The steroid sex hormone 17beta-estradiol (E(2)) has been shown to promote the… (More)

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