J. Gray

J. M. Lancaster1
P. A. Futreal1
P. Brunton1
J. O’Dwyer1
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The discovery of the amphibian skin tetradecapeptide bombesin led to the identification of several mammalian bombesin-like neuroendocrine peptides such as gastrin-releasing peptides (GRP'-27 and GRP"8-27) and neuromedin B. GRP and neuromedin B are products of two distinct genes (Krane et al., 1988). Bombesin and its homologues stimulate gastric acid(More)
Mutations in the BRCA1/BRCA2 genes account for varying proportions of breast cancer families studied, and demonstrate considerable variation in mutational spectra coincident with ethnic and geographical diversity. We have screened for mutations in 17 families from Wales with two or more cases of breast cancer under age 50 and/or ovarian cancer. Eight out of(More)
OBJECTIVE The aim of this study was to assess the cost effectiveness of silicone and alginate impressions for complete dentures. METHODS Cost effectiveness analyses were undertaken alongside a UK single centre, double blind, controlled, crossover clinical trial. Taking the perspective of the healthcare sector, effectiveness is measured using the EuroQol(More)
Blunt abdominal trauma is a rare but recognized cause of small bowel obstruction. We report a case of intestinal obstruction in a 33 year-old male who initially was reluctant to volunteer the history of abdominal trauma. The omission of this important information significantly influenced the patient's diagnosis and management. CASE REPORT A 33 year-old male(More)
Diabetic ketoacidosis is a well recognised, important, but rare differential diagnosis of acute abdominal pain in children. We report a case highlighting the need for complete assessment of any child presenting with new-onset glycosuria, ketonuria and hyperglycaemia. Causes other than diabetes may rarely produce these findings. CASE REPORT A girl aged three(More)
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