J. G. Westra

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The study of the binding of the liver carcinogen, N-acetyl-2-aminofluorene, to the DNA of the target organ-as the probable initial step in the process of carcinogenesis-has shown that three modes of interaction occur. N-Acetyl-2-aminofluorene is covalently bound with the nitrogen to the carbon 8 of guanine (I) and with the 3-position to the free NH(2)-group(More)
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