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It was discovered recently that infection by a protozoan parasite, Azumiobodo hoyamushi, is the most probable cause for soft tunic syndrome in an edible ascidian, Halocynthia roretzi (Drasche). In an attempt to develop measures to eradicate the causative parasite, various drugs were tested for efficacy in vitro and in vivo. Of the 20 antiprotozoal drugs(More)
Human and mouse proliferation-competent, bone marrow or peripheral circulation derived endothelial progenitor-like cells (EPCs) were isolated, expanded and genetically engineered ex vivo to express the beta galactosidase (β-gal), green fluorescence protein or thymidine kinase (TK) genes using retrovirus-mediated gene transfer. Genetically labeled EPCs were(More)
Malignant ascites is a common complication of advanced intraabdominal neoplasms for which standard treatments are suboptimal. Evidence suggests that tumor-mediated angiogenesis and enhanced vascular permeability in the peritoneal wall due to high levels of vascular endothelial growth factor play a fundamental role in the pathogenesis of malignant ascites.(More)
Sublimation of silver atoms from a nanometer-sized silver particle, namely, the crystalline-to-gas transition, has been directly observed by high resolution electron microscopy. Remarkable sublimation of silver atoms took place at 950 K from an approximately 9-nm-sized crystalline silver particle on the graphite substrate. The sublimation continued until(More)
Stark-shifted image-potential states were measured with an STM tip for benzene adsorbed on a Cu(111) surface. A single benzene molecule locally shifts the position of the first image state toward the Fermi level by 0.2 eV relative to its position on the clean surface. The energetic position of this molecule-modified state shifts to lower energy with(More)
Pyridine was chemisorbed on Cu(110) at 10 K and observed using STM at 5 K as dosed and after annealing to temperatures between 20 and 300 K. At very low coverage, two molecular species with different apparent heights are observed to coexist. The higher species is assigned to a pyridine molecule bonded with its symmetry axis perpendicular to the surface(More)
The adsorption of 4-picoline (4-methylpyridine) on the Cu(110) surface has been studied with time-of-flight electron stimulated desorption ion angular distribution (TOF-ESDIAD) and other methods. Using deuterium labeling in the methyl group and hydrogen labeling on the aromatic ring, it has been possible to separately monitor by TOF-ESDIAD the C-D bond(More)
We have established a fabrication process for conductive carbon nanotube (CNT) tips for multiprobe scanning tunneling microscope (STM) with high yield. This was achieved, first, by attaching a CNT at the apex of a supporting W tip by a dielectrophoresis method, second, by reinforcing the adhesion between the CNT and the W tip by electron beam deposition of(More)
We studied electronic-excitation-induced phase transformations in nanoparticles using transmission electron microscopy. GaSb particles excited by 75 keV electrons transform to two phases consisting of an antimony core and a gallium shell or an amorphous phase, or remain in the original crystalline phase, depending on particle size and/or temperature. It is(More)
Solid solubility in isolated nanometer-sized particles has been studied by in situ transmission electron microscopy using alloy particles in the Pb-Sn binary system. In approximately 17-nm-sized particles of a lead-56 at. % Sn solid solution, a phase change from a single phase of the lead solid solution to two phases, a lead solid solution and a tin-solid(More)
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