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The authors administered procarbazine, 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU, lomustine), and vincristine (PCV) to 86 patients with recurrent glioblastoma. There were three partial responses, but no complete responses. Median progression-free survival was 17.1 weeks and progression-free survival at 6 months was 38.4%. World Health Organization(More)
The objective of this study was to develop a simplified scoring system to predict 30-day mortality in patients with acute ischemic stroke. A retrospective cohort study was performed in a tertiary referral hospital in the Hunter Region of Australia. A prognostic index was created by assigning points to the variables in a Cox model. The index included(More)
Repeated electrical stimulation of the sensorimotor region of the rat cerebral cortex at 10-min intervals led to progressive lengthening of the self-sustained after-discharges (SSAD). 50-60 s after termination of the third SSAD we examined, in the electron microscope, type I synapses (after Gray) in the second cortical layer of the sensorimotor region of(More)
A projected epileptic focus was induced in the brains of experimental rats by applying penicillin G sodium to the contralateral hemisphere. Synapses of type I (after Gray) in the second cortical layer of the mirror area were analyzed morphometrically in the electron microscope 30 min after application of the epileptogenic drug. The number of agranular(More)
Infant rats, together with the female, were exposed daily from birth to the age of 17 days (except for the 6th, 7th, 13th and 14th day) to a simulated attitude of 7,000 m. On the 18th day, 20 hours after the last exposure to hypoxia, the animals were perfused. In each of 118 synapses from the two control animals and 162 synapses from the two experimental(More)