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Overactivation of certain K(+) channels can mediate excessive K(+) efflux and intracellular K(+) depletion, which are early ionic events in apoptotic cascade. The present investigation examined a possible role of the KCNQ2/3 channel or M-channel (also named Kv7.2/7.3 channels) in the pro-apoptotic process. Whole-cell recordings detected much larger(More)
Nuclear factor-kappaB is a transcription factor that regulates a variety of genes involved not only with immune and inflammatory responses, but also in cell survival. Nuclear-factor kappaB in the CNS is an area of current research interest; however, its role in age-related neural degeneration is obscure. The present study examines developmental degeneration(More)
We investigated the role of calcium (Ca(2+))/calmodulin (CaM) signaling pathways in modulating GABA synaptic transmission at CA1 pyramidal neurons in hippocampal slices. Whole-cell pipettes were used to record type A GABA receptor (GABA(A)R)-gated inhibitory postsynaptic currents (IPSCs) and to perfuse intracellularly modulators in the presence of glutamate(More)
were attenuated by co-infusing colchicine (30 ␮M), vincris-tine (3 ␮M) or cytochalasin D (1 ␮M) that inhibits tubulin or actin polymerization, implying that actin filament and micro-tubules are involved. We conclude that postsynaptic Ca 2؉-CaM signaling pathways strengthen the function of GABAer-gic synapses via a cytoskeleton-mediated mechanism, probably(More)
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