J. F. Svetlik

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OBJECTIVES Dihydropyridine calcium channel blockers have some disadvantages such as light sensitivity and relatively short plasma half-lives. Stability of dihydropyrimidines analogues could be of advantage, yet they remain less well characterized. We aimed to test four newly synthesized Biginelli-type dihydropyrimidines for their calcium channel blocking(More)
A synthesis of novel pyrazolopyridine, benzopyranopyrazolopyridine, and oxygen-bridged pyrazolo-, tetrazolo-, benzimidazo-, and thiazolopyrimidines via Hantzsch- and Biginelli-like condensations has been developed. The ability of these compounds to inhibit Eg5 activity has been examined. The results indicate that synthetic manipulations in the monastrol(More)
Presented Models describe the current growth rate. These models are good tools for growth prediction in the near future and will be compareable with further models; they will demonstrate the Norway spruce growth changes considering the climate change. Tree growth depends on genetic, climatic, microsite conditions and stand structure variations. A new(More)
The X-ray structure analysis of the unexpected product of the reaction between 4-(4-methylphenyl)but-3-en-2-one and aminoguanidine revealed the title compound, C(12)H(17)N(4)(+) x -C(2)H(3)O(2)(-) x 0.5C(3)H(6)O, consisting of a protonated amidine moiety joined to a substituted pyrazoline ring at the N1 atom. The amidine group is protonated and the positive(More)
The affinity of two compounds, closely related to 1,4-dihydropyridines, was determined in competition binding experiments using canine cerebral cortex membranes and [3H]nitrendipine as a radioligand. Some aspects of structure-affinity relationships are discussed in relation to existing models of the dihydropyridine binding site.
Voltage-gated Ca2+ channels are the major pathway of Ca2+ entry into the cells. Their activity is essential to couple electrical signals from the cell surface to physiological events in cells. Several pharmacologically, structurally and kinetically distinct calcium channel types have been identified at the electrophysiological and molecular levels. This(More)
The title compound, C14H11NO4, consists of a methoxy-substituted coumarin skeleton fused to a 2-methyl-4-pyridone ring. The ring system of the molecule is approximately planar and the methoxy group is roughly coplanar with the ring plane. The 4-pyridone ring exists in a 4-hydroxy tautomeric form and is stabilized by an intramolecular hydrogen bond between(More)
There are two crystallographically independent mol-ecules in the asymmetric unit of the title compound, C(21)H(18)N(4)O(4). The substituted benzopyran portion of one of the independent mol-ecules exhibits disorder [occupancy 0.5248 (18):0.4752 (18)], which was modelled by using two sets of atomic positions and restraints on the chemically equivalent bond(More)
The reaction between 4-(4-methylphenyl)but-3-en-2-one and aminoguanidine produced an unexpected product of formula C(12)H(15)N(3)O, consisting of a carboxamide moiety joined to a substituted pyrazoline ring at one of the N atoms. The pyrazoline ring adopts a flat-envelope conformation and the substituted phenyl ring is oriented almost perpendicular to the(More)