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Recent research has suggested that serotonin, in addition to dopamine, may be involved in the development of attention deficit hyperactivity disorder (ADHD). Serotonin regulates dopaminergic neurotransmission in some areas of the brain via several 5-HT receptors including 5-HT1B. Animal studies have suggested the involvement of the 5-HT1B receptors in(More)
253 A central premise in the " catecholamine hypothesis " of attention-deficit/hyperactivity disorder (ADHD) is that dopam-ine (DA) dysfunction leads to clinical symptoms. The hypothesis arises, in part, from the clinical efficacy of methylphenidate, as well as evidence from brain imaging studies that suggest reduced activity in frontal-striatal regions.(More)
A recent study demonstrated that treatment of hyperactive mice with psychostimulants and serotonergic agents produced a calming effect that was dependent on serotonergic neurotransmission and was not associated with any changes in extracellular dopamine levels. The complex interaction between the serotonergic and dopaminergic neurotransmitter systems(More)
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