J. -F. Petit

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In the following pages we intend to update and to expand a previous review 'The Mycobacterial cell wall' published in 19711 . Many new facts on the chemical structure have come to light since then and the last few years have witnessed a rapid expansion of our knowledge of the interesting biological properties of compounds derived from the cell walls of(More)
The present report confirms that L1210 leukemia can be prevented by administration — in saline — of “interphase material” (IPM) which is a composite preparation extracted from nonpathogenic mycobacteria, such as M. smegmatis. IPM was more active than the different BCG cell wall preparations tested under the same conditions (i.e., in saline). The activity of(More)
The first two sections give a historical introduction describing the identification of a muramyl-dipeptide as the smallest adjuvant active moiety capable of replacing whole killed mycobacterial cells in Freund's complete adjuvant. This molecule, MDP (for muramyl-dipeptide = N-acetyl-muramyl-L-alanyl-D-isoglutamine) was synthesized and shown to be fully(More)
Vesicles consisting of pure trehalose dicorynomycolate (TDCM), the corynebacterial analog of the most studied mycobacterial glycolipid 'cord factor', were isolated from Corynebacterium glutamicum cells by mild detergent treatment; these induced in vivo a macrophage priming similar to that obtained with mycobacterial-derived trehalose dimycolate. In vitro,(More)
Intratracheal (i.t.) administration of trehalose dimycolate (TDM) in saline as liposomes induces a transient inflammatory effect. Limited granulomas appeared in some peribronchial areas but most subsided after a few weeks. The alveolar macrophages were activated as judged by their cytostatic activity against the syngeneic P77 fibrohistiocytoma 3 days after(More)
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