J F Brandstater

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The ability of 5-hydroxyl-L-tryptophan (5-HTP) or pentobarbital anesthesia to elevate rat serum GH levels is completely blocked by the simultaneous administration of the serotonin antagonist cyprophepatidine, as well as by the pineal gland principles melatonin and 5-methoxytryptamine (5-MT), and by the 0-methylated dopamine derivative (More)
The acute administration of the monoamine oxidase inhibitor iproniazid to rats causes a highly significant suppression of serum prolactin levels at 2 h. At the same time there is a significant rise in the hypothalamic-median eminence concentrations of the biogenic monoamines dopamine, noradrenaline and serotonin. When iproniazid is administered daily to(More)
A simple method for the assay of brain biogenic amines by selected-ion monitoring was applied to examination of the effects of 3-iodo-L-tyrosine on the hypothalamic-median eminence concentrations of dopamine, noradrenaline and serotonin in the rat. Thirty minutes after its administration iodotyrosine (50 mg/kg) caused a highly significant (P less than(More)
The acute administration of lithium chloride significantly inhibits both prolactin and growth hormone secretion in the rat. In terms of known neuroendocrine relationships this finding indicates that lithium administration alters both dopamine (DA) and serotonin (5-HT) activity in the hypothalamus. The data suggest that DA activity is increased (inhibiting(More)
The induction of hyperprolactinaemia in the male rat following chronic high-dose oestrogen administration over 3 months was associated with a significant inhibition of the secretion of growth hormone (GH) (P less than 0.02) thyroid stimulating hormone (TSH) (p less than 0.0025), luteinizing hormone (LH) and follicle stimulating hormone (FSH) (both P less(More)
The induction of hyperprolactinaemia in the male rat following chronic oestrogen administration over 3 months was shown to result in a highly significant reduction in hypothalamic dopamine (DA) concentration as well as significant reductions in hypothalamic noradrenaline (NA) and serotonin (5-HT). Significant increases in hypothalamic DA synthesis were(More)
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