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Tumor-necrosis factor (TNF), a pleiotropic cytokine, triggers physiological and pathological responses in several organs. Here we show that deletion of the mouse gene Timp3 resulted in an increase in… Continue Reading
Using in vivo gene transfer, we examined the anti-inflammatory potential of transforming growth factor-beta 1 (TGF-beta 1) in the renal glomerulus. TGF-beta 1 cDNA, modified to allow for secretion of… Continue Reading
Insulin-like growth factors I and II (IGF-I and -H) are peptide mitogens that exert a wide range of biological actions in many tissues and cell types. The actions of the IGFs include metabolic and… Continue Reading