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1. The voltage dependence and kinetic properties of stage 40 ciliary ganglion calcium currents were determined using short (10 ms) voltage steps. These properties aided the interpretation of the action potential-evoked calcium current described below, and the comparison of our data with those observed in other preparations. 2. Three different natural action(More)
Most calcium channels are tightly regulated, closed in the resting cell, and open only in response to specific physiological signals such as depolarization or binding of a particular ligand. In addition, calcium permeable channels which can be activated experimentally by excising a small patch of plasma membrane from the cell have been described in several(More)
The effects of the alkali metal ions cesium (Cs+) and rubidium (Rb+) and alkaline earth metal ions barium (Ba2+) and strontium (Sr2+) on ganglionic transmission in various calcium (Ca2+) concentrations were investigated in rat isolated superior cervical ganglia. Cesium (1 and 2 mM) moderately supported transmission in low Ca2+ and potentiated the compound(More)
Patch clamp methods were used to study the effect of lipopolysaccharide (LPS), an endotoxin produced by gram-negative bacteria, on voltage-dependent outward current of lung pericytes. Pericytes are located in capillary walls and may mediate pathological changes in microvascular hemodynamics and permeability that accompany endotoxin-mediated pulmonary edema.(More)
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