J E P Sams

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ABSTRACT. Group B β-hemolytic Streptotocci cause pulmonary hypertension when injected into animals and may precipitate the persistent pulmonary hypertension syndrome in infected human neonates. We used chronically instrumented piglets to study the effects of repeated injections of heat-killed group B Streptococcus (GBS) type III. Daily exposure to GBS was(More)
We have shown that heat-killed Group B Streptococci (GBS) cause dose-related pulmonary artery hypertension in chronically instrumented piglets. These responses are similar to those seen with gram negative bacterial endotoxins. Prostanoids and endorphins have been implicated as mediators of these responses. We tested the effect of a cycloxygenase inhibitor,(More)
Infusions of Group B Streptococci; (GBS) cause pulmonary hypertension in acutely instrumented lambs. We developed a chronic piglet model to further study this response. We placed a pulmonary artery electromagnetic flow transducer plus pulmonary, aortic, left atrial and central venous catheters. After > 4 days recovery, animals were given 1×108 heat killed(More)
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