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A preponderance of females develop autoimmune disease, including juvenile idiopathic arthritis (JIA), yet the reason for this bias remains elusive. Evidence suggests that genetic risk of disease may be influenced by sex. PTPN22 rs2476601 is associated with JIA and numerous other autoimmune diseases, and has been reported to show female-specific association(More)
Methods Data from TB screening by tuberculin skin test (TST) and interferon gamma release assay (Quantiferon TB Gold In tube, (IGRA)) involving at-risk children with rheumatic disease was reviewed. Exposed patients were considered to be at moderate risk of LTBI if they were under 5 years of age, or receiving conventional DMARDs or corticosteroids > 0.5(More)
Background Juvenile Idiopathic Arthritis (JIA) is a complex autoimmune disorder likely to be determined by multiple genetic and environmental factors. Mounting evidence shows that epigenetic variation influences autoimmune disease risk. The most well-studied epigenetic mark is DNA methylation; increased methylation of CpG dinucleotides can reduce gene(More)
Background Juvenile idiopathic arthritis (JIA) is a complex disease determined by both genetic and environmental factors. Whilst prior research has provided preliminary evidence for some factors, most studies have been hindered by small sample sizes and low statistical power. It is clear that to successfully identify causal factors for complex diseases,(More)
Introduction Systemic juvenile idiopathic arthritis (sJIA) shares clinical features with classic monogenic autoinflammatory diseases, characterised by fevers, arthritis and evanescent rashes. Disease exacerbations are associated with elevated serum cytokine levels including 1L-1b, IL-6, and IL-18; and clinical response to anakinra, canakinumab and(More)
Methods The RCH Rheumatology Database was used to identify all children diagnosed with JIA at RCH in 2009 according to ILAR (2001). The families of those who had undertaken education were invited to complete the questionnaire used previously in the AMQuiP project. The questionnaire surveyed satisfaction regarding information provided about: ∎ JIA ∎(More)
Introduction The causes of autoimmune diseases, including juvenile idiopathic arthritis (JIA) are presumed to involve the interplay of genes and environment. Vitamin D interacts with genes via vitamin D response elements (vdres). The gene PTPN2, associated with various autoimmune diseases including JIA, carries a VDRE and is regulated by vitamin D.(More)
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