J E Mercer

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A role for activin in the acquisition of gonadotropin responsiveness by the post-natal rat ovary was investigated. The inhibin/activin subunits in terms of protein and mRNA, were localised in granulosa cells of the rat ovary at days 4, 8 and 12 after birth. A characteristic pattern of responses to FSH for inhibin and progesterone (P) production was(More)
We have investigated the effect of bilateral adrenalectomy at 116-119 days' gestation on the levels of the messenger (m) RNA for proopiomelanocortin (POMC) in the anterior pituitary of the fetal sheep and in the ovine placentome during late gestation (134-136 days' gestation). After fetal adrenalectomy there was a significant (p less than 0.001) and(More)
In this study the levels of mRNA for the pituitary gonadotropin hormone subunits luteinizing hormone beta (LHbeta), follicle stimulating hormone beta (FSHbeta) and the common alpha-subunit were assessed during the acute feedback stages of estradiol benzoate (EB) action in ovariectomized (OVX) ewes with and without hypothalamo-pituitary disconnection (HPD).(More)
Proopiomelanocortin (POMC) gene expression in the anterior pituitary (AP) gland has previously been shown to be positively regulated by CRF and AVP and negatively regulated by glucocorticoids. In the neurointermediate lobe (NIL) of the pituitary, however, POMC gene expression is under tonic inhibitory dopaminergic control. In the present study we have used(More)
A computer program has been developed to calculate inviscid transonic flow over a swept wing in a wind tunnel with specified normal flow at the walls. An approximately orthogonal computational grid which conforms to the wing and the tunnel walls was developed for application of the Jameson-Caughey finite volume algorithm. the full potential equations in(More)
The effect of gonadotropin-releasing hormone (GnRH) and/or estradiol (E2) on pituitary messenger ribonucleic acid (mRNA) levels of luteinizing hormone beta (LH beta), follicle-stimulating hormone beta (FSH beta) and the common alpha-subunit were determined in anterior pituitary glands from ovariectomized (OVX) ewes. Hypothalamo-pituitary disconnected (HPD)(More)
Abstract Levels of mRNA for the common a subunit and for the beta subunits of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) were measured in the pituitary glands of ovariectomized hypothalamo-pituitary disconnected ewes. A control group (n = 7) received 250 ng pulses of gonadotrophin-releasing hormone (GnRH) each hour for one week. To(More)
Long-term effects of gonadotropin-releasing hormone (GnRH) and/or estrogen on pituitary mRNA levels for the beta-subunit of luteinizing hormone (LH-beta) were determined in anterior pituitary glands from ovariectomized (OVX) ewes. The relative roles of these two factors were assessed by studying hypothalamopituitary disconnected (HPD) ewes with appropriate(More)
Hypothalamo-pituitary disconnected sheep were given gonadotropin releasing hormone pulses every 2 h for 1 week, and the effects of inhibin on mRNA for FSH beta, LH beta, alpha-subunit and prolactin examined. Levels of FSH beta mRNA were reduced to approximately 20% 6 h after administration, and to approximately 10% by 30 h; no change was seen in LH beta,(More)
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