J. E. H. Shaw

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BACKGROUND Spinocerebellar ataxia type 2 (SCA2) is a recently delineated cause of autosomal dominant cerebellar ataxia type I. The basic clinical neurologic features of SCA2 have been described in the literature, but neuropsychological features have not, despite statements that some patients became demented. OBJECTIVE To describe the clinical and(More)
We report our observations in an Australian family with spinocerebellar ataxia type 14 (SCA 14). We describe a novel mutation in exon 5 of the PRKCG gene, altering a highly conserved cysteine to a phenylalanine at codon 150, and record the detailed clinical observations in six affected family members.
In this paper we show how a simple parametrization, built from the definition of cubic splines, can aid in the implementation and interpretation of penalized spline models, whatever configuration of knots we choose to use. We call this parametrization value-first derivative parametrization. We perform Bayesian inference by exploring the natural link between(More)
Well—mainly for statistics. This is a collection of about 2,000 quotations from the famous, (e.g., Hippocrates: 'Declare the past, diagnose the present, foretell the future'), the infamous (e.g., Stalin: 'One death is a tragedy, a million deaths is a statistic'), and the cruelly neglected (modesty forbids.. .). Such quotes help me to: • appeal to a higher(More)
J is both a formal mathematical language and a general-purpose programming language, implemented on a wide range of computers. It handles vectors, matrices, higher-dimensional arrays and more complicated data structures in a consistent and efficient way. Thus J is an ideal tool both for research and for day-today programming. Like many powerful mathematical(More)
J is both a formal mathematical language and a general-purpose programming language, implemented on a wide range of computers. It handles vectors, matrices, higher-dimensional arrays and more complicated data structures in a consistent and eecient way. Thus J is an ideal tool both for research and for day-today programming. Like many powerful mathematical(More)
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