J E Elledge

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Protein kinase C (PKC) plays a central role in the control of proliferation and differentiation of a wide range of cell types by mediating the signal transduction response to hormones and growth factors. Upon activation by diacylglycerol, PKC translocates to different subcellular sites where it phosphorylates numerous proteins, most of which are(More)
In Escherichia coli, mutagenesis by agents such as ultraviolet light, methyl methanesulfonate and 4-nitroquinoline-1-oxide is not a passive process. Rather, it requires the intervention of a cellular system that processes damaged DNA in such a way that mutations result. This type of processing is referred to as "error prone repair". This process can be(More)
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