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Arginine-8-vasopressin (AVP) levels were measured by a sensitive and specific radioimmunoassay (RIA) in plasma and cerebrospinal fluid (CSF) of three species man, dog, and rat (Wistar and the Brattleboro strain). Basal plasma values were 1.7 pg/ml in Wistar rat, and 2.4 pg/ml in dog. Pentobarbitone, used as anesthetic during collection of CSF from dog and(More)
Vasopressin, oxytocin, neurophysin I and neurophysin II have been detected and quantitatively determined in the bovine pineal gland. The neurohormones and the neurophysins are present in all parts of the gland. The oxytocin concentration, however, is higher in the anterior part than in the posterior one. The ratio of oxytocin to vasopressin appears to be(More)
Since vasopressin and oxytocin might be involved in processes of storage and retrieval of information in rats, the distribution of these hormones within the central nervous system was measured employing sensitive and specific radioimmunoassays in combination with an extraction method using Vycor glass powder. Vasopressin was detected in hypothalamus,(More)
The demonstration of vasotocin in the mammalian pineal gland, subcommissural organ and fetal pituitary gland by bioassay has led to hypotheses regarding the function of this hormone in various reproductive processes. Preliminary examinations of the pineal gland and subcommissural organ with a specific radioimmunoassay failed to show vasotocin(More)
The pituitary contents of oxytocin, vasopressin and alpha-MSH were measured in fetal and newborn rats to assess possible changes in their release during the process of labour. In the 24 h period during which delivery is likely to occur in the Wistar rat, both the oxytocin and vasopressin content of the fetal pituitary gland increased, whereas alpha-MSH(More)
The effect of epidural analgesia on oxytocin release during the second stage of normal labour was studied by comparing 10 primigravidae who had epidurals with 10 control subjects who did not have epidurals. A significant increment in oxytocin between paired peripheral blood samples taken at the onset of full cervical dilatation and crowning of the fetal(More)