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The International Campaign for Cures of Spinal Cord Injury Paralysis (ICCP) supported an international panel tasked with reviewing the methodology for clinical trials in spinal cord injury (SCI), and making recommendations on the conduct of future trials. This is the first of four papers. Here, we examine the spontaneous rate of recovery after SCI and(More)
BACKGROUND The Spinal Cord Injury Locomotor Trial (SCILT) compared 12 weeks of step training with body weight support on a treadmill (BWSTT) that included overground practice to a defined but more conventional overground mobility intervention (CONT) in patients with incomplete traumatic SCI within 8 weeks of onset. No previous studies have reported(More)
Study design:Experts opinions consensus.Objective:To develop a common strategy to document remaining autonomic neurologic function following spinal cord injury (SCI).Background and Rationale:The impact of a specific SCI on a person's neurologic function is generally described through use of the International Standards for the Neurological Classification of(More)
Objective: To compare the efficacy of step training with body weight support on a treadmill (BWSTT) with over-ground practice to the efficacy of a defined over-ground mobility therapy (CONT) in patients with incomplete spinal cord injury (SCI) admitted for inpatient rehabilitation. Methods: A total of 146 subjects from six regional centers within 8 weeks of(More)
Study design:Double-blind, randomized, placebo-controlled, parallel-group clinical trial.Objective:Assess safety and efficacy of sustained-release fampridine in subjects with chronic spinal cord injury.Setting:A total of 11 academic rehabilitation research centers in the United States.Methods:A total of 91 subjects with motor-incomplete spinal cord injury(More)
Study design:Review by the spinal cord outcomes partnership endeavor (SCOPE), which is a broad-based international consortium of scientists and clinical researchers representing academic institutions, industry, government agencies, not-for-profit organizations and foundations.Objectives:Assessment of current and evolving tools for evaluating human spinal(More)
BACKGROUND Timed walking speed for 6 to 15 m and the distance walked in 2 to 12 minutes are frequently used outcome measures in rehabilitation trials, presumably reflecting different aspects of walking ability. The database from the Spinal Cord Injury Locomotor Trial (SCILT), which tested 2 interventions for mobility upon admission for initial(More)
MH Tuszynski*, JD Steeves, JW Fawcett, D Lammertse, M Kalichman, C Rask, A Curt, JF Ditunno, MG Fehlings, JD Guest, PH Ellaway, N Kleitman, PF Bartlett, AR Blight, V Dietz, BH Dobkin, R Grossman and A Privat Department of Neurosciences, Center for Neural Repair, University of California,-San Diego, La Jolla, CA, USA; Department of Neurology, Veterans(More)
MS Alexander, F Biering-Sorensen, D Bodner, NL Brackett, D Cardenas, S Charlifue, G Creasey, V Dietz, J Ditunno, W Donovan, SL Elliott, I Estores, DE Graves, B Green, A Gousse, AB Jackson, M Kennelly, A-K Karlsson, A Krassioukov, K Krogh, T Linsenmeyer, R Marino, CJ Mathias, I Perkash, AW Sheel, G Shilero, B Schurch, J Sonksen, S Stiens, J Wecht, LA(More)
JD Steeves*, D Lammertse, A Curt, JW Fawcett, MH Tuszynski, JF Ditunno, PH Ellaway, MG Fehlings, JD Guest, N Kleitman, PF Bartlett, AR Blight, V Dietz, BH Dobkin, R Grossman, D Short, M Nakamura, WP Coleman, M Gaviria and A Privat ICORD, University of British Columbia (UBC) and Vancouver Coastal Health (VCH) Research Institute, Vancouver, BC, Canada; Craig(More)
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