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In this work, we formulate a parameter estimation problem for a large-scale dynamic metabolic network. The DAE system represents the dynamic model for the Embden-Meyerhof-Parnas pathway, the phosphotransferase system and the pentose-phosphate pathway of Escherichia coli K-12 W3110 (Chassagnole et al., 2002), with modifications on several enzyme kinetics and(More)
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