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The pharmacokinetics of florfenicol (FF), thiamphenicol (TP) and chloramphenicol (CP) after single intravenous (i.v.) or oral (p.o.) administration was studied in an independent cross-over study in broiler turkeys. All the fenicol antibiotics were administered at a dose of 30 mg/kg b.w. and their concentrations in plasma samples were assayed using the same(More)
Normothermic rabbits and rabbits with LPS induced fever were treated with chlormethine (Nitrogranulogen, Ntg) in the doses of 1 microgram/kg and 10 micrograms/kg. The blood was collected 4, 24, 48 hrs and 4, 7, 10 days after Ntg injection. Following indices of immunity were studied: T and B cells number, number of IgM producing cells after immunization with(More)
The cold stress induced in rabbits by lowering their body temperature by 3 degrees C resulted in neutrophilia and a decrease in number of phagocytes and phagocytized bacteria. The stress did not affect the number of lymphocytes and the ability of forming E rosettes by T lymphocytes, but depressed the formation of EAC rosettes by B lymphocytes. This(More)
The studies on normothermic rabbits show that intravenous administration of Tołpa Peat Preparation (TPP) at a dose of 5 mg/kg for 3 or 6 consecutive days increases the percentage of phagocytizing cells and the number of bacteria phagocytized by a single neutrophil. The stimulated phagocytic activity of neutrophils coincides with increased nitroblue(More)
The studies were carried out on Balb/c mice (5-6 weeks of age) exposed to immunosuppression by a single intraperitoneal dose (125 mg/kg) of hydrocortisone. Prior to hydrocortisone injection the mice were treated with diethyldithiocarbamate (DTC) intra-peritoneally at a dose of 20 mg/kg, five times at 48 h intervals or calf thymus extract (TFX) at a dose of(More)
Acetylsalicylic acid (300 mg/kg), mefenamic acid (30 mg/kg) or indomethacin (20 mg/kg) given orally in the doses preventing the postpyrogenic fever, inhibited the stimulatory effect of LPS on phagocytic and killing activity of neutrophils. The dose of acetylsalicylic acid that did not eliminate fever in rabbits (100 mg/kg), had no suppressive effect upon(More)
The effect of low doses of mechlorethamine (1-10 micrograms/kg) and levamisole (2.5 mg/kg) on humoral response of rabbits immunized twice with ovalbumin (0.1 mg/kg) was compared. It was shown that mechlorethamine given in a dose of 5 or 10 micrograms/kg potentiates the increase in the level of serum anti-ovalbumin hemagglutinins; this increase is induced(More)
The effect of low-dose mechlorethamine (5 micrograms/kg) on secondary humoral response to sheep red blood cells (SRBC), depending on time of exposure to the drug in relation to priming and challenge was studied in Balb/c mice. It was found that mechlorethamine in a dose of 5 micrograms/kg stimulated primary humoral response to SRBC resulting in the(More)
The studies were conducted on Balb/c mice exposed to restraint stress twice for 12 h at 24 h intervals. Some of the experimental mice were immunized i.p. with sheep red blood cells (SRBC). The antigen was injected before the first exposure of the mice to restraint stress, or immediately after the second loading was ended. Sodium diethyldithiocarbamate (DTC)(More)