J. D. Cooper

J. A. Todd3
J. M. M. Howson2
N. M. Walker2
B. Akolkar1
3J. A. Todd
2J. M. M. Howson
2N. M. Walker
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AIMS/HYPOTHESIS We used recently confirmed type 2 diabetes gene regions to investigate the genetic relationship between type 1 and type 2 diabetes, in an average of 7,606 type 1 diabetic individuals and 8,218 controls, providing >80% power to detect effects as small as an OR of 1.11 at a false-positive rate of 0.003. METHODS The single nucleotide(More)
AIMS/HYPOTHESIS Over 50 regions of the genome have been associated with type 1 diabetes risk, mainly using large case/control collections. In a recent genome-wide association (GWA) study, 18 novel susceptibility loci were identified and replicated, including replication evidence from 2,319 families. Here, we, the Type 1 Diabetes Genetics Consortium (T1DGC),(More)
AIMS/HYPOTHESIS Insulin-like growth factor-1 is a major childhood growth factor and promotes pancreatic islet cell survival and growth in vitro. We hypothesised that genetic variation in IGF1 might be associated with childhood growth, glucose metabolism and type 1 diabetes risk. We therefore examined the association between common genetic variation in IGF1(More)
Stable perfectly-matched-layer boundary conditions for finite-difference time-domain simulation of acoustic waves in piezoelectric crystals. Abstract Perfectly matched layer (PML) boundary conditions are derived for finite-difference time-domain analysis of acoustic waves within piezoelectric crystals. The robustness and effectiveness of the derived(More)
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