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  • J Corsin
  • Journal of embryology and experimental morphology
  • 1975
Parts of cephalic neural crest of Pleurodeles waltlii have been cultivated in vitro alone or in explants containing other cellular components. It was hoped that these experiments would establish under what conditions cephalic neural crest cells can differentiate into chondroblasts. It has been demonstrated that this differentiation is possible only under(More)
Sodium hyaluronate, present in large quantities during cellular multiplication and the migration phase, is not found in the extracellular matrix during early chondrocyte differentiation. Microinjections enabled a higher concentration of hyaluronate to be maintained than in normal embryos. This leads to the appearance of anomalies in the cartilage structure;(More)
As revealed in chondrogenetic cells the LDH activity that is very low during cellular migration, suddenly increases at the time of cytodifferentiation and reaches a peak at the onset of the first chondrocyte differentiation. A relationship is likely to exist between this increase in LDH-activity, chondroitin-sulfate synthesis and NAD metabolism.
The importance of cell-matrix interactions during terminal chondrocyte differentiation is to-day accepted by all authors. Na-hyaluronate micro-injections induce an increase of perichondral thickness and maintain mesenchymal aspect in chondrocyte. Cytoplasmic organelles show anomalies which may be bound to disturbance in cellular metabolism. An important(More)
  • J Corsin
  • Journal of embryology and experimental morphology
  • 1977
During the differentiation of cranial cartilages the composition of perichordal and perineural extracellular matrix changes: at first only collagen and hyaluronic acid can be detectese while the concentration of hyaluronic acid is decreasing. The possible effects of these substances not only on the chondrogenetic cells but also between themselves are(More)
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