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The role of the raphe nuclei (RN) in sleep and waking has been investigated in 35 male Wistar rats. After an habituation period to their environment, the rats were continuously recorded (24 h/day), during a 5 day period prior to the lesioning of one or several RN and thereafter during 22 days. The daily slow wave sleep (SWS) and paradoxical sleep (PS)(More)
After continuous control recording (24 h/day) during 5 days, 14 rats received sham, complete or incomplete lesions of the suprachiasmatic nuclei (SCN). Sleep records were analysed from the 22nd to the 27th day after the lesion. In rats with complete lesions of the SCN, there was a strong decrease in the amplitude of the circadian variation in slow wave(More)
The effects of i.p. injections of adenosine (Ado) and homocysteine at 17.00 h were tested on the rat sleep-waking cycle. Administration of 7 and 50 mg/kg of Ado resulted in a significant increase in sleep in otherwise saline male rats during the environmental-dark period (18.00-06.00 h). Increments of paradoxical sleep were maximal with the smaller dose of(More)
S-adenosyl-L-homocysteine (SAH) was administered to normal and pinealectomized rats previously implanted with electrodes for polygraphic recording. In normal rats, injected at 17.00 h, 7 mg/kg SAH induced a significant increase of paradoxical sleep (PS) during the night. When injected at 09.00 or 19.00 h, no effect was observed. In pinealectomized rats, SAH(More)
The effect on the sleep-waking cycle of low intensity electrical stimulation (0.2 mA intensity, 80 Hz frequency, 0.7 ms signal duration) within the lateral ventricles was studied in rats maintained under a photoperiod of 12 h light and 12 h darkness (lights on at 06.00 h). When stimulation was performed at 1700 h for 3 min, there was a significant immediate(More)
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