J. Chris Fisher

Learn More
Following DNA damage, nuclear p53 induces the expression of PUMA, a BH3-only protein that binds and inhibits the antiapoptotic BCL-2 repertoire, including BCL-xL. PUMA, unique among BH3-only proteins, disrupts the interaction between cytosolic p53 and BCL-xL, allowing p53 to promote apoptosis via direct activation of the BCL-2 effector molecules BAX and(More)
Traditionally, well-defined three-dimensional structure has been thought to be essential for protein function. However, myriad biological functions are performed by highly dynamic, intrinsically disordered proteins (IDPs). IDPs often fold upon binding their biological targets and frequently show 'binding diversity' by targeting multiple ligands. We sought(More)
1] constructed complete (q2-q + l)-arcs in PG(2, q2), q > 3. One of the interesting properties of these arcs is the fact that they are fixed by a cyclic protective group of order q2 — q + 1. We investigate the following problem: What are the complete k-arcs in PG(2, q) which are fixed by a cyclic projective group of order k? This article shows that there(More)
A theoretical basis is offered for the remarkable observation by Oriani and Fisher [1] of a shower of about 250,000 energetic charged particles that occurred in the vapor of oxygen and hydrogen evolved from electrolysis. The shower was localized in space and in time, originating a few millimeters above the surface of a plastic detector chip and lasting for(More)
Polyneutron theory is applied to nuclear transmutation. Implications of the theory are compared with experiment. Additional more definitive experiments are suggested. Polyneutron theory postulates that large clusters of neutrons are bound and stable against strong decay and that their interactions with ordinary nuclei are responsible for a new class of(More)
A projective bundle in PG(2, q) is a collection of q 2 + q + 1 conics that mutually intersect in a single point and hence form another projective plane of order q. The purpose of this paper is to investigate the possibility of partitioning the q 5 − q 2 conics of PG(2, q) into q 2 (q − 1) disjoint projective bundles. As a by-product we obtain a multiplier(More)
  • 1