J. C. da Costa

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In the present work we measured blood levels of total homocysteine (tHcy), vitamin B12 and folic acid in patients with Parkinson´s disease (PD) and in age-matched controls and searched for possible associations between these levels with smoking, alcohol consumption, L-DOPA treatment and disease duration in PD patients. We initially observed that plasma tHcy(More)
Transplantation of autologous bone marrow mononuclear cells (BMMCs) has been proven safe in animal and human studies. However, there are very few studies in stroke patients. In this study, intra-arterial autologous BMMCs were infused in patients with moderate to severe acute middle cerebral artery infarcts. The subjects of this study included 20 patients(More)
PURPOSE To identify brain dominance for language functions with DLT and correlate these results with those obtained from fMRI in patients suffering from intractable temporal lobe epilepsy. METHOD This study reports on 13 patients who underwent pre-surgical epileptic evaluation between April and October 2004 at the Epilepsy Surgery Program, Hospital Sao(More)
A winner-take-all (WTA) single-electron neuron is developed for the first time. This new single-electron circuit is proposed in order to implement a WTA neural network with lateral inhibition architecture. An expression for the neuron’s activation function is presented. Furthermore, a dot pattern recognition task is successfully performed by the implemented(More)
OBJECTIVE The aim of this study was to verify incidence and characteristics of sudden unexpected death in patients (SUDEP) with refractory epilepsy and its relation to previous surgery and lesion localization. METHOD A cross sectional study was carried out in a cohort of 550 patients with refractory epilepsy followed up by the Epilepsy Surgery Program of(More)
OBJECTIVE To describe the neurological outcome of newborns with seizures. METHOD Cohort study with newborns prospectively followed. Perinatal characteristics and etiological screening were related to outcome in a regression model. RESULTS During the study 3,659 newborns were admitted and 2.7% were diagnosed as having seizures. Hypoxic ischemic(More)
UNLABELLED Seizures are the most frequent neurological event in newborns and clinical data suggest that etiology is the dominant factor in long term outcome. However, there are consistent background EEG abnormalities associated to neonatal seizures that are usually related to unfavorable outcome as the burst-suppression pattern. OBJECTIVE The objective of(More)
UNLABELLED There are individuals who have a progressive language deficit without presenting cognitive deficits in other areas. One of the diseases related to this presentation is primary progressive aphasia (PPA). OBJECTIVE Identify by means of diffusion tensor imaging (DTI) and measurements of cortical volume, brain areas that lead to dysphasia when(More)
PURPOSE Interest in the association of epilepsy and pseudobulbar palsy was rekindled since the identification through magnetic resonance imaging (MRI) of bilateral perisylvian polymicrogyria (PMG). Seizures are often intractable, but resective epilepsy surgery has not been recommended. However, a similar clinical picture can be encountered in patients with(More)
Objectives: to investigate the socio-epidemiologic characteristics of the victims of sudden infant death syndrome and to calculate its prevalence during the 1st year of life. Methods: this is an observational, retrospective, and descriptive study based on the review of autopsy protocols and questionnaires applied to families that had cases of infants death(More)