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BACKGROUND Polo-like kinase 1 (Plk1) has an important role in mitosis. Volasertib (BI 6727), a potent and selective cell cycle kinase inhibitor, induces mitotic arrest and apoptosis by targeting Plk; this phase I study sought to determine its maximum tolerated dose (MTD) in Asian patients with advanced solid tumours. METHODS Patients were enrolled(More)
This research aims to build a Wireless Technology Enhanced Classroom (WiTEC) that supports everyday activities unobtrusively and seamlessly in classroom contexts. This paper describes the integration of wireless LAN, wireless mobile learning devices, an electronic whiteboard, an interactive classroom server, and a resource and class management server to(More)
The tremendous advance in computer technology in the past decade has made it possible to achieve the performance of a supercomputer on a very small budget. We have built a multi-CPU cluster of Pentium PC capable of parallel computations using the Message Passing Interface (MPI). We will discuss the configuration, performance, and application of the cluster(More)
This study studies the effects of machine breakdown, backlog and rework on the replenishment lot size. In real-life manufacturing systems, random defective rate and breakdown of equipment are inevitable. When backlogging is permitted during a production run, a random machine failure may take place either in backlog filling stage or in inventory piling time;(More)
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