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A reliable short-term NaCl taste test was developed for rats which resulted in differential responding to a variety of concentrations. The rats were required to exist on a low sodium diet for 8-10 days prior to the initiation of testing. The peak response in this test was to isotonic NaCl with lesser responding to hyper- and hypotonic solutions. After(More)
The literature is divided over whether a conditioned taste aversion (CTA) can be fully extinguished. In Experiment 1, we created a powerful aversion in 54 rats by pairing the taste of 0.0025 M NaSaccharin (CS) with intraperitoneal injections of 127 mg/kg LiCl (US) on 3 occasions. We then offered 23-h deprived rats NaSaccharin for 10 min/day to observe the(More)
Comparative mapping, which compares the location of homologous genes in different species, is a powerful tool for studying genome evolution. Comparative maps suggest that rates of chromosomal change in mammals can vary from one to ten rearrangements per million years. On the basis of these rates we would expect 84 to 600 conserved segments in a chicken(More)
The number of licks during 30-s exposures to a range of concentrations of sucrose, glucose, fructose, maltose, and Polycose were recorded. A complete series of concentrations of each carbohydrate was offered in ascending, descending, or random order with 30-s intertrial intervals. The order of presentation differed on different days. For sucrose, glucose,(More)
Complex interventions, which have been shown to improve primary care depression outcomes, are difficult to disseminate to routine practice settings. To address this problem, we developed a brief intervention to train primary care physicians and nurses employed by the practice to improve the detection and management of major depression. Before recruitment(More)
Despite its relevance for quality care initiatives, the field of psychiatry has little scientific knowledge regarding the course of current major depression when primary care patients with the disorder remain undetected. Using statewide telephone screening, we identified and followed 98 adults with current major depression who made one or more visits to a(More)
BACKGROUND There is a need to research interventions that improve access to and convenience of breast cancer screening services. METHODS We conducted a randomised trial comparing invitations to out-of-hours appointments with standard office hour appointments. Women who were to be invited for routine breast screening were randomised (3 : 1 : 1 : 1) to one(More)
We compared the potencies of systemic administration of bombesin (BN) and its mammalian homologue gastrin-releasing peptide (GRP) to decrease sham feeding in rats. Bombesin (at doses of 8, 16 and 32 micrograms/kg, intraperitoneally) inhibited sham feeding by 37% (p < 0.001), 58% (p < 0.001) and 65% (p < 0.001), respectively, confirming previous results.(More)