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We studied the activation and interaction of cortical motor regions during simple, internally paced and externally paced right-hand finger extensions in healthy volunteers. We recorded EEGs from 28 scalp electrodes and analysed task-related coherence, task-related power and movement-related cortical potentials. Task-related coherence reflects inter-regional(More)
OBJECTIVES To define patients at risk for unplanned extubation; to assess the influence of nursing workload on the incidence of unplanned extubation; and to determine predictive criteria for patients requiring reintubation. DESIGN A prospective, case-control study, with 10 and 15 mos of data collection. SETTING University medical intensive care(More)
Venous thromboembolism after total hip replacement continues to be a serious problem. We conducted a study to determine whether adjustment of the dose of subcutaneous heparin to yield partial thromboplastin times in the high-normal range results in a greater reduction of postoperative deep-vein thrombosis than fixed doses of heparin. Seventy-nine patients(More)
INTRODUCTION Intrahospital transport (IHT) of mechanically ventilated critically ill patients is associated with an important risk of complications. OBJECTIVES The purpose of this study was to assess the incidence of complications occurring during the IHT and to analyse the causes and the consequences of such complications. PATIENTS AND METHODS All the(More)
STUDY OBJECTIVE To compare the effects of noninvasive assist-control ventilation (ACV) and pressure support ventilation (PSV) by nasal mask on respiratory physiologic parameters and comfort in acute hypercapnic respiratory failure (AHRF). DESIGN A prospective randomized study. SETTING A medical ICU. PATIENTS AND INTERVENTIONS Fifteen patients with(More)
Dear Editor, Driving pressure of respiratory system (ΔP) is the difference between plateau pressure (Pplat) and total positive end-expiratory pressure (PEEPtot). ΔP has recently been shown to be a strong predictor of mortality in patients with acute respiratory distress syndrome (ARDS) [1–3]. However, in most of these studies Pplat was measured 0.5 s after(More)
This study was designed to evaluate the utility of positron emission tomography (PET) to quantify the magnitude and spatial distribution of transgene expression after different methods of adenoviral vector delivery (with surfactant- and saline-based vehicles) within rat lungs. In all, 17 animals (eight in the surfactant group, nine in the saline group) were(More)
BACKGROUND A study was undertaken to investigate the effects of non-invasive assist-control ventilation (ACV) by nasal mask on respiratory physiological parameters and comfort in acute on chronic respiratory failure (ACRF). METHODS Fifteen patients with chronic obstructive pulmonary disease (COPD) were prospectively and randomly assigned to two(More)
Peripheral blood mononuclear cells (PBM) from a patient who had lived in a malarial-endemic area were cultured in the presence of malarial antigens (a lysate of Plasmodium-infected erythrocytes). Responding cells were grown in IL-2-containing medium and then cloned, and subsequently subcloned, in the presence of phytohemagglutinin and allogeneic irradiated(More)
OBJECTIVE Fluoxetine is widely prescribed for depressed patients. Hyponatremia secondary to inappropriate secretion of antidiuretic hormone has been reported in a few cases associated with routine use of fluoxetine, especially in elderly patients. The mechanism has been postulated to be linked to the inappropriate secretion of antidiuretic hormone. Serum(More)