J C Pechère

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Originally described in bacteria, drug transporters (or efflux pumps) are now recognized as major determinants in the modulation of the accumulation and efflux of antibacterials in virtually all cell types, from prokaroytes to superior eukary-otes. Transport proteins are in fact major cellular products. Based on sequence similarities with known transporters(More)
Originally described in bacteria, drug transporters (or efflux pumps) are now recognized as major determinants in the modulation of the accumulation and efflux of antibacterials in virtually all cell types, from prokaroytes to superior eukary-otes. Transport proteins are in fact major cellular products. Based on sequence similarities with known transporters(More)
One group of newborn rats were given 50 mg/kg gentamicin for 20 days, 8 days after birth and were housed during the treatment in a regular incubator. They were compared to a similar group housed in regular cages and to two groups of unintoxicated newborn rats, one being exposed to the incubator noise and one being unexposed. Incubator noise was found to(More)
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