J. C. Ong

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We present an approach to the optimal fitting of a biarc-spline to a given B-spline curve. The objective is to minimize the area between the original B-spline curve and the fitted curve. Such an objective has obvious practical implications. This approach differs from conventional biarc curve-fitting techniques in two main aspects and has some desirable(More)
Sensorimotor gating disruptions are seen in various psychiatric illnesses with putatively different pathologies, including schizophrenia and bipolar disorder. Interestingly, mice lacking the dopamine (DA) transporter (DAT) gene display markedly increased levels of DA, deficits in sensorimotor gating, and hyperactivity relative to wild-type mice. Atypical(More)
Acutely manic bipolar patients, like patients with schizophrenia, Tourette's syndrome, panic disorder, and obsessive compulsive disorder, exhibit deficits in sensorimotor gating, as measured by prepulse inhibition (PPI) of the startle response. Here, we assessed the ability of four drugs used in the treatment of bipolar mania-phenytoin, carbamazepine,(More)
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