J. C. Lecoq

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Fluorescence Ca(2+) imaging enables large-scale recordings of neural activity, but collective dynamics across mammalian brain regions are generally inaccessible within single fields of view. Here we introduce a two-photon microscope possessing two articulated arms that can simultaneously image two brain areas (∼0.38 mm(2) each), either nearby or distal,(More)
IFP 1.4. The fluorescence spectra of the two molecules are similar, with an excitation maximum of 684 nm for IFP 1.4 versus 690 nm for iRFP, and with emission maxima of 708 nm and 713 nm, respectively. The molecular brightness of iRFP is estimated to be ~20% greater than that of IFP 1.4 when the two are compared in vitro. However, the big gains from iRFP(More)
A major technological goal in neuroscience is to enable the interrogation of individual cells across the live brain. By creating a curved glass replacement to the dorsal cranium and surgical methods for its installation, we developed a chronic mouse preparation providing optical access to an estimated 800,000-1,100,000 individual neurons across the dorsal(More)
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