J C Buxtorf

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500 mg of probucol were given twice a day for 6 months to 20 type II hyperlipoproteinemic patients, 14 men and 6 women, including 10 type IIb and 10 type IIa cases. Tendon xanthomas were present in 11 and xanthelasma in 4. Their mean blood cholesterol level was 435 +/- 100 mg/100 ml and triglycerides 210 +/- 138 mg/100 ml. A normal diet was maintained(More)
Seasonal variations of blood lipids, which must be considered when performing long-term studies, could be partially due to dietary changes. In the present study, serum lipid parameters were measured each month for 1 year in nuns living in a monastery, whose diet was perfectly regular and controlled. The serum lipid variations observed consisted mainly of an(More)
In this study Probucol transport and the effect of the drug on lipoprotein composition in 9 cases of type IIa hypercholesterolemia were investigated. Probucol lowered plasma cholesterol by 20%, without affecting triglycerides. HDL cholesterol was decreased and a slight reduction in LDL cholesterol was noted. This was due to a reduction in the number of(More)
Free and esterified cholesterol in the skin were assayed by gas chromatography after thin layer histochromatographic separation. There were 20 controls of both sexes, 36 subjects with type lla hyperlipoproteinemia, 27 with type IIb hyperlipoproteinemia and 19 with type IV hyperlipoproteinemia. Esterified skin cholesterol levels were higher in women with the(More)
Twenty-two hyperlipidemic and long-term alcoholic patients were chosen as subjects with a chronic alcohol-dependent hyperlipoproteinemia, since their lipidemia was getting normal after they stopped alochol ingestion. After ethanol-weaning of these subjects, we found quantitative abnormalities of lipidemia (hypocholesterolemia in 5 cases among 22) and(More)
A new technique is described for the determination of cholesterol in skin biopsies which is sensitive, practical and reproducible. The determination of cutaneous cholesterol is of clinical interest, because of its correlation with the degree of atherosclerosis. There was no correlation found between the blood total cholesterol and total triglycerides, and(More)
Oral administration of large doses of vitamin A permits one to study pos-prandial lipemia. Thanks to a new fluorescimetric and automatic method, estimation of vitamin A is now much easier than formerly. The normal results of the oral vitamin A tolerance test are evaluated with this new method and compared with those given by the previous method.