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A genetically restricted allogeneic effect factor (AEF) derived from a mixed lymphocyte culture reaction between Ia-negative activated responder cells and irradiated T-cell-depleted stimulator cells was characterized. Restricted AEF is a B-cell-derived soluble helper factor which consists in part of Ia antigens controlled by the I-A subregion of the(More)
On the basis of studies with immunoadsorbent columns, many soluble, lymphocyte-derived, helper and suppressor factors, which mediate T-cell B-cell macrophage interaction during antibody synthesis, have been shown to consist of H-2-1inked I-region associated (Ia) 1 antigens (1-3). It has been postulated that/-region genes also determine the putative(More)
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