J Barnswell

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The acute metabolic responses to metabolic acidosis in the rat include an increase in ammoniagenesis and gluconeogenesis before enzyme adaptations have taken place. In the present studies rats were made acidotic with NH4Cl or HCl. Preincubation of renal cortical slices from normal rats in plasma from acidotic rats produced an increase in ammoniagenic(More)
In chronic metabolic acidosis in the rat, there is increased ammoniagenesis, gluconeogenesis and renal extraction of glutamine with induction of renal phosphate-dependent glutaminase (PDG). Because the stimulus for these changes is not yet clear and also because acute acidosis is the more common clinical problem, the present study deals mainly with the(More)
Rats develop metabolic acidosis acutely after exercise by swimming. Renal cortical slices from exercised rats show an increase in both ammoniagenesis and gluconeogenesis from glutamine. In addition, plasma from the exercised rats also stimulates ammoniagenesis in renal cortical slices from normal rats. In exercised rats renal phosphate dependent glutaminase(More)
Chronic metabolic acidosis causes several biochemical changes in the rat kidney: perhaps the most prominent of these is the increase in ammonia production from glutamine and the increase in activity of phosphate-dependent glutaminase [ 11. The changes with acute acidosis are less clear and although there is an early increase in total renal production of(More)
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