J. B. Le Pecq

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Tyrosine phosphorylation plays a crucial role in cell proliferation and cell transformation which suggests that tyrosine kinase-specific inhibitors might be used as anticancer agents. When the cytotoxic effect of the potent tyrosine kinase inhibitor genistein on various cell lines was studied, we observed that 9-hydroxyellipticine-resistant Chinese hamster(More)
because, as fully discussed by Skipper et a!. (16), the few cells that escape the therapy are rapidly able to nepopulate the organism. Therefore, a complete cure cannot be ob tamed. It would thus be of great practical importance fully to understand this phenomenon. Three different explana tions of this heterogeneous response of the tumor cells to drugs in(More)
Tyrosine phosphorylation plays a crucial role in cell proliferation and cell transformation which suggests that tyrosine kinase-specific inhibitors might be used as anticancer agents. When the cytotoxic effect of the potent tyrosine kinase inhibitor genistein on various cell lines was studied, we observed that 9-hydroxyellipticine-resistant Chinese hamster(More)
The kinetics of a model reaction between the antitumor drug as-diamminedichloroplatinum(ll) (c/s-DDP) and the signal nucleotide diadenosine S'.S^-P'.PMetraphosphate (Ap^A) has been investigated by spectrophotometry. The formation of the reactive platinum aquated species was first analyzed by potentiometry using a chloride-specific electrode. Both(More)
Ditercalinium (NSC 335153), a bifunctional intercalating molecule with antitumor activity, is found to express its toxicity through a mech anism of action completely different from that of other monointercalating agents. Electron microscopic observation of ditercalinium-treated cells shows a drastic alteration of mitochondria! structure. Cells deficient in(More)
Comparative 1H NMR and optical studies of the interaction between poly(dA-dT), ethidium bromide (Et) and ethidium dimer (Et2) in 0.7 M NaCl are reported as a function of the temperature. Denaturation of the complexes followed at both polynucleotide and drug levels leads to a biphasic melting process for poly(dA-dT) complexed with ethidium dimer (t1/2 = 75(More)
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