J. B. Collip

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SINCE the year 1889, when von Mering and Minkowski (1) preduced severe and fatal diabetes by total removal of the pancreas in dogs, many investigators have endeavoured to obtain some beneficial effect in diabetes mellitus, either by feeding pancreas, or by administration of pancreatic extracts. Minkowski, Sandmeyer (2), Pfluger (3) and others found that(More)
BRAIER [1931], Corkill et al. [1933] and others have noted that adrenaline may partially or wholly fail to cause elevation of the blood sugar in hypophysectomized animals. Since the increase in blood lactate is also subnormal [Chaikoff et al. 1935a; Marks, 1936], and since the muscle glycogen is the chief source of the sugar mobilized by adrenaline in(More)