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This study investigated the effects of strenuous live-fire firefighting drills and a 90 min recovery period on selected hormonal, immunological and psychological variables. Apparently healthy, male, professional firefighters (n = 11) performed three trials of standardized firefighting tasks in a live-fire training structure. There was significant(More)
Estrogen receptors (ERs) are expressed in the thymus of both males and females, but their role in thymic development and function is unclear. To determine whether ERalpha plays a role in thymic function of either males or females, we compared thymuses of male and female wild-type (WT) and ERalpha knockout (alphaERKO) mice from birth to adulthood. Although(More)
STUDY DESIGN Mechanobiology study of gene expression changes as a result of compressive overload of anular fibrochondrocytes. OBJECTIVE To test hypotheses regarding phenotype shift in genes coding for representative extracellular matrix (ECM) proteins and matrix modulators. SUMMARY OF THE BACKGROUND DATA In degenerative disc disease, the transfer of(More)
SUMMARY The main theme of this paper is the modelling error associated with the choice of constitutive equations and associated parameter sensitivity. These key concepts are ÿrst discussed in a general way and explored in detail subsequently for three ow application problems which share certain similarities not only in the ÿnite element formulation but also(More)
RSR13[2-(4[[(3,5-Dimethylanilino)carbonyl] methyl] phenoxy)-2-methyl propionic acid], a synthetic allosteric modifier of hemoglobin, increases O2 release from hemoglobin at low oxygen tension. The isolated blood-perfused rat heart was examined during potassium-arrest to determine the effects of RSR13 on the concentration of phosphocreatine (PCr) and(More)
The zeta-subunit of the TCR binds GTP and is a well characterized substrate for a TCR-activated tyrosine kinase. To examine the possible coupling of GTP-binding to zeta with TCR-mediated signal transduction, a mutant (termed J32-3.2) of the T cell line Jurkat (J32) was used. Anti-TCR/CD3 stimulation of the TCR/CD3+ J32-3.2 cells resulted in a weak(More)
Increased synthesis of alpha-fetoprotein (AFP) was induced in rat liver by the administration of 3'-methyl-4-dimethyl-aminoazobenzene. The indirect immunoperoxidase technique was used to detect AFP. Cellular localization of AFP was studied using a number of different fixation procedures. Serial sections stained with immunoglobulin served to determine the(More)
The different porcelain-metal junction angulations from 45 to 135 degrees have no effect on the amount of compressive force required to fracture the porcelain. The compressive force required to fracture the samples was reduced by half when the contacts were placed 1 or 2 mm from the porcelain-metal junction. Nevertheless, even at 2 mm from the(More)