J. A. Ulrich Hachmann

Learn More
The paracaspase domain of MALT1 (mucosa-associated lymphoid tissue lymphoma translocation protein 1) is a component of a gene translocation fused to the N-terminal domains of the cellular inhibitor of apoptosis protein 2. The paracaspase itself, commonly known as MALT1, participates in the NF-κB (nuclear factor κB) pathway, probably by driving survival(More)
A general purpose neurocomputer, SYNAPSE-1, which exhibits a multiprocessor and memory architecture is presented. It offers wide flexibility with respect to neural algorithms and a speed-up factor of several orders of magnitude--including learning. The computational power is provided by a 2-dimensional systolic array of neural signal processors. Since the(More)
Receptor tyrosine kinases (RTKs) are co-deregulated in a majority of glioblastoma (GBM), the most common and most deadly brain tumor. We show that the RTKs MET, EGFR, and PDGFR regulate microRNA-134 (miR-134) in GBM. We find that miR-134 is downregulated in human tumors and cancer stem cells and that its expression inversely correlates with the activation(More)
This paper describes the general purpose neurocomputer SYNAPSE–1 which has been developed in cooperation between Siemens Munich and the University of Mannheim. This system contains one of the most powerful processors available for neural algorithms, the neuro signal processor MA16. The prototype system executes a test algorithm 8,000 times as fast as a(More)
8 0740-7475/03/$17.00 © 2003 IEEE Published by the IEEE Computer Society IEEE Design & Test of Computers A MAJOR CHALLENGE for automobile designers is to improve driver safety and comfort. For this reason, driver assistance systems will play an important role in upcoming generations of intelligent vehicles. Early applications such as night vision (based on(More)
The human paracaspase MALT1 is a caspase homolog that plays a central role in NF-κB signaling. Over the past few years it has become clear that this is due to a combination of its scaffolding and proteolytic function. Knockout mice and mice expressing a catalytically dead variant of the protease have provided valuable information. This review aims to(More)
The human paracaspase mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) plays a central role in nuclear factor-κB (NF-κB) signaling as both a protease and scaffolding protein. Knocking out MALT1 leads to impaired NF-κB signaling and failure to mount an effective immune response. However, it is unclear to which degree it is the(More)